Tangle - Netflix

The story two generations of two families; colliding, connecting and sometimes at cross-purposes as they navigate their way around the maze of love, sex, money and politics. Now you can watch all three seasons of this critically acclaimed Australian drama series on BoxSets on demand via Foxtel's Anytime service.

Tim Williams has the world at his feet. Tipped for a top job in Cabinet, he is well on his way to becoming Premier. With a happy marriage, a good relationship with his teenage son and respect from his peers, his future is looking great. There's only one little problem: 15 years ago, Tim had a brief, ill judged affair with drug-loving wild-child Nat Manning. The affair ended in pregnancy. After confessing to his wife Christine, they patched up their marriage and fought bitterly for custody of the child, Max.

Nat fled to London and has barely been heard from since. Now 10 years on, Nat is a mere smear on the landscape of the Williams' hard won, happy lives.

But Nat is back … and there is a secret undercurrent to the world into which she returns. Her sister, Ally, is living in domestic oblivion. Unaware that her husband, Vince, is having an affair, Ally is also blind to the fact that his best friend, Gabriel, is in love with her. She is oblivious to Vince's plans: a builder with ambition to jump into the big league, Vince can almost smell the possibility of a life of power, money and sex. If Tim Williams is going to climb the political ladder, then Vince is determined to extract his own benefits through their secret family connection.

But Nat has a way of exposing what's hidden.

And through it all, the teenage children of Ally and Vince, Nat, Tim and Christine, and Vince's mistress Em, are busily creating their own generation of chaos as they discover sex, danger, and the thrills of oncoming adulthood.

Tangle - Netflix

Type: Scripted

Languages: English

Status: Ended

Runtime: 60 minutes

Premier: 2009-10-01

Tangle - Neurofibrillary tangle - Netflix

Neurofibrillary tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary marker of Alzheimer's disease. Their presence is also found in numerous other diseases known as tauopathies. Little is known about their exact relationship to the different pathologies.

Tangle - Harmful or protective? - Netflix

There has been some suggestion that the formation of NFTs does not have a causal relationship with disease. Rather that NFTs may be produced in response to a variety of conditions and may in fact be a compensatory response against oxidative stress and serves a protective function. Several points are made to argue the position that NFTs are perhaps protective instead of harmful. First there appears to be a dispute as to the impact of neurofibrillary tangles on neuronal viability because some neurons containing NFTs survive for decades. Furthermore, NFTs have been found in apparently healthy individuals, indicating that NFTs are not directly related to neural degeneration. It has been proposed that the formation of NFTs is part of a multifaceted compensatory response where oxidative insult activates several kinases, which are then capable of phosphorylating tau. This then prompts the early formation of NFTs, which reduce oxidative damage and prolong the function of the neuron. While an intriguing theory, scientists have not come to a firm conclusion as to what role NFTs play in neurodegenerative diseases. Results from the new study suggest that a specific phosphorylation of tau (at threonine-205) has a protective effect on neurons in a mouse model of excitotoxic, amyloid beta toxicity. The authors suggest that the reason tau becomes modified is to protect from damage caused by amyloid protein aggregation. A protein called kinase p38γ phosphorylates tau at the threonine-205 amino acid. The activity of this gamma kinase enzyme is mostly lost as Alzheimer Disease progresses, suggesting a loss of this protective effect. Reintroducing p38γ and increasing its activity prevented memory deficits from occurring in their mouse model, suggesting this enzyme as a potential target for future therapies. However increasing the activity of kinases has been shown to be difficult).

Tangle - References - Netflix